Cannabinoids for neuropathic pain.

Treatment of Neuropathic Pain: Opioids, Cannabinoids, and Topical Agents - Printer-friendly version

1. To review the mechanisms and eff ects of opioids, cannabinoids, and topical agents in neuropathic pain. 2. To review clinically relevant pharmacokinetics and pharmacodynamics of opioids, cannabinoids, and topical agents in patients with neuropathic pain. 3. To review the clinical evidence for the use of opi-oids, cannabinoids, and topical agents in neuro-pathic pain.

Cannabinoids and neuropathic pain.

After a brief overview of the endocannabinoid system (CB receptors, and endocannabinoids) and of the cannabinergic ligands, some general issues related to cannabinoids and pain are commented. Finally, the most important findings regarding cannabinoids and neuropathic pain are discussed in detail.

Recent data on cannabinoids and their pharmacological implications in neuropathic pain

Natural cannabinoids have been used for centuries for their psychotropic properties, but their possible therapeutic implications in analgesia have been recently documented. The present review intended to make an analysis of the neuroanatomy and physiology of the cannabinoid system (receptors, functions, agents acting on these receptors) and of its implications in neuropathic pain. There were al...

Recent developments in the therapeutic potential of cannabinoids.

OBJECTIVE To examine the recent evidence that marijuana and other cannabinoids have therapeutic potential. METHODS Literature published since 1997 was searched using the following terms: cannabinoid, marijuana, THC, analgesia, cachexia, glaucoma, movement, multiple sclerosis, neurological, pain, Parkinson, trial, vomiting. Qualifying clinical studies were randomized, double-blind, and placebo...

Cannabinoids and Neuropathic Pain